mTOR Pathway: Leucine Threshold vs. Total Protein

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SlavPower
Posts: 36
Joined: Mon Dec 08, 2025 3:19 am

mTOR Pathway

Post by SlavPower »

Starting a deep dive into leucine thresholds...
Herbertysnilm
Posts: 2
Joined: Mon Jan 12, 2026 12:44 am

Re: Cardio Impact

Post by Herbertysnilm »

Left Ventricular Hypertrophy (LVH) is almost inevitable for long term heavy users. The question is management of blood pressure.
Herbertysnilm
Posts: 2
Joined: Mon Jan 12, 2026 12:44 am

Re: Cardiovascular Impact

Post by Herbertysnilm »

The heart is a muscle. If you give it orals and heavy gear for a decade, Left Ventricular Hypertrophy (LVH) is a statistical certainty.
MedellinMuscle
Posts: 13
Joined: Mon Dec 08, 2025 3:25 am

Re: mTOR Pathway

Post by MedellinMuscle »

The 3g threshold is often cited, but bodyweight matters.
MedellinMuscle
Posts: 13
Joined: Mon Dec 08, 2025 3:25 am

Re: Cardio Impact

Post by MedellinMuscle »

Telmisartan is the gold standard for AAS users. It treats the BP and has some slight PPAR-delta activity for lipids.
MedellinMuscle
Posts: 13
Joined: Mon Dec 08, 2025 3:25 am

Re: Cardiovascular Impact

Post by MedellinMuscle »

It’s the concentric remodeling that’s dangerous. Aerobic work (LISS) can help induce eccentric remodeling to counter the "thickening" of the heart walls.
Peterdyday
Posts: 1
Joined: Sat Jan 03, 2026 7:16 pm

Re: mTOR Pathway

Post by Peterdyday »

I’ve noticed better recovery with 5g leucine per meal.
SlavPower
Posts: 36
Joined: Mon Dec 08, 2025 3:19 am

Re: Cardiovascular Impact

Post by SlavPower »

Does anyone here donate blood regularly to keep hematocrit down? I find it helps with the "heavy heart" feeling on high doses.
SlavPower
Posts: 36
Joined: Mon Dec 08, 2025 3:19 am

Re: Cardio Impact

Post by SlavPower »

Hematocrit management is key too. Thick blood puts massive strain on the heart during heavy lifting.
SlavPower
Posts: 36
Joined: Mon Dec 08, 2025 3:19 am

Re: mTOR Pathway

Post by SlavPower »

Is there an upper limit where it becomes redundant?
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