HPTA Restart: Meta-Analysis of PCT Protocols

Herbertysnilm · Post by **Herbertysnilm** » Fri Sep 27, 2024 4:07 am

That would explain why some SARMs have a much longer biological half-life than their plasma half-life suggests.

MedellinMuscle · Post by **MedellinMuscle** » Fri Sep 27, 2024 10:53 am

Day 2 of looking at these charts. The Ostarine affinity is so low compared to S4, yet Ostarine is more popular. Marketing vs Science.

SlavPower · Post by **SlavPower** » Fri Sep 27, 2024 12:27 pm

Ostarine is popular because the side effect profile is manageable for beginners. High affinity SARMs like YK-11 are essentially steroids.

Peterdyday · Post by **Peterdyday** » Fri Sep 27, 2024 4:03 pm

YK-11 is a steroidal SARM anyway. Its structure is based on 19-nor. No wonder the binding is aggressive.

CoachIronwell · Post by **CoachIronwell** » Fri Sep 27, 2024 6:50 pm

I think we need more research on how these interact with SHBG. SARMs usually crush SHBG levels faster than traditional AAS.

Herbertysnilm · Post by **Herbertysnilm** » Fri Sep 27, 2024 9:37 pm

Which leads to more free estrogen and potential gyno issues, despite the lack of aromatization. Science is vital here.

MedellinMuscle · Post by **MedellinMuscle** » Sat Sep 28, 2024 1:47 am

Great point. The "SARM-only" cycle often fails because people ignore the endocrine feedback loop.

SlavPower · Post by **SlavPower** » Sat Sep 28, 2024 5:57 am

Does anyone have the full study on the S23 binding in canine models? I heard it was used as a male contraceptive.

Peterdyday · Post by **Peterdyday** » Sat Sep 28, 2024 10:07 am

Yes, S23 is so suppressive it was studied for that exact reason. Not something to take lightly without a test base.

CoachIronwell · Post by **CoachIronwell** » Sat Sep 28, 2024 2:17 pm

This thread should be stickied. Too many people taking these as "supplements" without understanding the AR affinity.