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Re: SARM Binding Affinity
Posted: Fri Sep 27, 2024 4:07 am
by Herbertysnilm
That would explain why some SARMs have a much longer biological half-life than their plasma half-life suggests.
Re: SARM Binding Affinity
Posted: Fri Sep 27, 2024 10:53 am
by MedellinMuscle
Day 2 of looking at these charts. The Ostarine affinity is so low compared to S4, yet Ostarine is more popular. Marketing vs Science.
Re: SARM Binding Affinity
Posted: Fri Sep 27, 2024 12:27 pm
by SlavPower
Ostarine is popular because the side effect profile is manageable for beginners. High affinity SARMs like YK-11 are essentially steroids.
Re: SARM Binding Affinity
Posted: Fri Sep 27, 2024 4:03 pm
by Peterdyday
YK-11 is a steroidal SARM anyway. Its structure is based on 19-nor. No wonder the binding is aggressive.
Re: SARM Binding Affinity
Posted: Fri Sep 27, 2024 6:50 pm
by CoachIronwell
I think we need more research on how these interact with SHBG. SARMs usually crush SHBG levels faster than traditional AAS.
Re: SARM Binding Affinity
Posted: Fri Sep 27, 2024 9:37 pm
by Herbertysnilm
Which leads to more free estrogen and potential gyno issues, despite the lack of aromatization. Science is vital here.
Re: SARM Binding Affinity
Posted: Sat Sep 28, 2024 1:47 am
by MedellinMuscle
Great point. The "SARM-only" cycle often fails because people ignore the endocrine feedback loop.
Re: SARM Binding Affinity
Posted: Sat Sep 28, 2024 5:57 am
by SlavPower
Does anyone have the full study on the S23 binding in canine models? I heard it was used as a male contraceptive.
Re: SARM Binding Affinity
Posted: Sat Sep 28, 2024 10:07 am
by Peterdyday
Yes, S23 is so suppressive it was studied for that exact reason. Not something to take lightly without a test base.
Re: SARM Binding Affinity
Posted: Sat Sep 28, 2024 2:17 pm
by CoachIronwell
This thread should be stickied. Too many people taking these as "supplements" without understanding the AR affinity.