RoidsNet Forum

Hypertrophy isn't just about protein synthesis; it's about the donation of nuclei from satellite cells. How does exogenous chemistry accelerate this process?

Resistance training is arguably the most potent non-pharmacological intervention for GLUT4 translocation. The contraction-mediated glucose uptake is independent of insulin.

Which is why "backloading" carbs only on training days works so well. You’re essentially shuttling glucose into a sink that doesn’t require a massive insulin spike.

I’ve tracked my fasted glucose for 6 months. On heavy squat days, my morning glucose the following day is consistently 5-8 mg/dL lower.

Does anyone here use Berbsrine or Metformin to amplify this? I find Metformin blunts my hypertrophy but Berberine seems to hit the sweet spot.

Metformin inhibits mTOR. If you are chasing maximum growth, avoid it around the training window. Berberine is safer as a GDA.

Actually, the mTOR inhibition from Metformin is often overstated in the fitness community. In moderate doses, the AMPK activation is beneficial for long-term metabolic health.