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Liver Toxicity Markers: AST/ALT vs GGT in Athletes
Posted: Fri Sep 20, 2024 7:50 pm
by MedellinMuscle
AST and ALT are general markers, but GGT is often more specific to cholestasis. Why do we rarely see GGT discussed in "liver support" threads?
Re: HPTA Restart
Posted: Fri Sep 20, 2024 8:20 pm
by CoachIronwell
The primary takeaway from the recent meta-analysis is that Clomid is becoming secondary to Enclomiphene due to the isomer profile.
Re: HPTA Restart
Posted: Fri Sep 20, 2024 9:20 pm
by MedellinMuscle
Enclomiphene definitely shows better LH/FSH response with fewer of the emotional side effects associated with the zuclomiphene isomer.
Re: HPTA Restart
Posted: Fri Sep 20, 2024 11:10 pm
by Herbertysnilm
We also need to consider HCG timing. Using it during the cycle prevents Leydig cell atrophy, making the restart much smoother.
Re: HPTA Restart
Posted: Sat Sep 21, 2024 12:50 am
by SlavPower
Exactly. Waiting until 3 weeks post-long ester to start HCG is a dated protocol. The "Power PCT" model is far more evidence-based.
Re: HPTA Restart
Posted: Sat Sep 21, 2024 2:46 am
by Peterdyday
Does the meta-analysis mention Triptorelin? I know it was hyped as a one-shot restart, but the data on pituitary desensitization is scary.
Re: HPTA Restart
Posted: Sat Sep 21, 2024 4:43 am
by CoachIronwell
Triptorelin is high risk. The study suggests it should only be used as a last resort under strict medical supervision.
Re: HPTA Restart
Posted: Sat Sep 21, 2024 8:20 am
by MedellinMuscle
What about the duration? Most PCTs are 4 weeks, but the data suggests 6-8 weeks is better for long-term retention of gains.
Re: HPTA Restart
Posted: Sat Sep 21, 2024 12:30 pm
by Herbertysnilm
Agreed. Pituitary signaling returns fast, but testicular volume and function take longer to normalize.