Page 1 of 2
Caffeine and Power Output: The Genetic Factor
Posted: Tue Jan 27, 2026 2:30 am
by LatinoBulk
Are you a fast or slow metabolizer? The CYP1A2 gene determines if caffeine helps or hurts your performance.
Re: Caffeine and Power Output: The Genetic Factor
Posted: Tue Jan 27, 2026 3:25 am
by MedellinMuscle
Slow metabolizers can actually see a decrease in performance if they dose too close to training.
Re: Caffeine and Power Output: The Genetic Factor
Posted: Tue Jan 27, 2026 4:10 am
by AndeanLifter
I have noticed that. 400mg makes me jittery and weak, 100mg is my sweet spot.
Re: Caffeine and Power Output: The Genetic Factor
Posted: Tue Jan 27, 2026 5:00 am
by TropicStrength
I'm a fast metabolizer. I can drink a double espresso and nap 30 mins later.
Re: Caffeine and Power Output: The Genetic Factor
Posted: Tue Jan 27, 2026 5:50 am
by CaliFlex
Does the timing change for slow metabolizers?
Re: Caffeine and Power Output: The Genetic Factor
Posted: Tue Jan 27, 2026 6:45 am
by LatinoBulk
Yes, they should dose at least 60-90 mins before. Fast metabolizers can do 30-45 mins.
Re: Caffeine and Power Output: The Genetic Factor
Posted: Tue Jan 27, 2026 7:30 am
by MedellinMuscle
What about the effect on calcium release in the muscle?
Re: Caffeine and Power Output: The Genetic Factor
Posted: Tue Jan 27, 2026 8:15 am
by AndeanLifter
Caffeine increases sarcoplasmic reticulum calcium release. Direct mechanism for force production.
Re: Caffeine and Power Output: The Genetic Factor
Posted: Tue Jan 27, 2026 8:55 am
by TropicStrength
It also lowers RPE. You just feel like the weight is lighter.
Re: Caffeine and Power Output: The Genetic Factor
Posted: Tue Jan 27, 2026 9:40 am
by LatinoBulk
Has anyone tried the 23andMe test for this?