HPTA Restart: Meta-Analysis of PCT Protocols

[MedellinMuscle]

Meta-analysis shows that HCG during a cycle preserves Leydig cell sensitivity. Why do so many still wait until the cycle is over to start recovery?

[MedellinMuscle]

The data on RAD-140 is particularly interesting. Its Ki value suggests an affinity almost rivaling dihydrotestosterone.

[Peterdyday]

True, but affinity doesn't always equal intrinsic activity. We need to look at the co-regulator recruitment post-binding.

[SlavPower]

I agree with @DataDriven_Lift. If the SARM binds but doesn't recruit the right co-activators in bone tissue, the selective part of SARM is lost.

[CoachIronwell]

Has anyone seen the latest 2025 paper on LGD-3033? The binding curve is significantly steeper than the older 4033 variant.

[Herbertysnilm]

From a clinical standpoint, the higher the affinity, the more suppression we generally see at the HPTA level. There is no free lunch.

[MedellinMuscle]

@CommonSenseMD exactly. People forget these are still androgens. Competitive binding at the hypothalamus is inevitable.

[SlavPower]

Is there any evidence of S3 selective binding in prostate tissue for the newer compounds?

[Peterdyday]

Minimal. Most "selectivity" in marketing is just lower overall potency masked as tissue-specific action.

[CoachIronwell]

We should also discuss the dissociation rate. How long the molecule stays bound to the AR determines the genomic response.