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Estrogen Rebound After Stopping AI

Posted: Sat Jan 24, 2026 2:30 am
by CoachIronwell
Problem: I finished my AI protocol 4 days ago and now my nipples are sensitive again.

Context:
* Was using Arimidex 0.5mg EOD.
* Stopped cold turkey after cycle ended.

The Mechanics:


Is this just a standard rebound because Arimidex doesn't destroy the enzyme? Should I have tapered off?

Re: Rebound Management

Posted: Sat Jan 24, 2026 4:00 am
by SlavPower
Yes, Arimidex is notorious for this. The enzymes are just "busy" while on the drug, then they all release at once.

Re: Rebound Management

Posted: Sat Jan 24, 2026 5:15 am
by FrostFlex
Switch to Aromasin next time. It’s a suicide inhibitor, so no rebound.

Re: Rebound Management

Posted: Sat Jan 24, 2026 5:50 am
by CoachIronwell
Should I start a low dose of Nolva to block the receptors for now?

Re: Rebound Management

Posted: Sat Jan 24, 2026 6:45 am
by manish
Definitely. 20mg Nolva until the sensitivity dies down.