Caffeine and Power Output: The Genetic Factor

LatinoBulk · Post by **LatinoBulk** » Tue Jan 27, 2026 2:30 am

Are you a fast or slow metabolizer? The CYP1A2 gene determines if caffeine helps or hurts your performance.

MedellinMuscle · Post by **MedellinMuscle** » Tue Jan 27, 2026 3:25 am

Slow metabolizers can actually see a decrease in performance if they dose too close to training.

AndeanLifter · Post by **AndeanLifter** » Tue Jan 27, 2026 4:10 am

I have noticed that. 400mg makes me jittery and weak, 100mg is my sweet spot.

TropicStrength · Post by **TropicStrength** » Tue Jan 27, 2026 5:00 am

I'm a fast metabolizer. I can drink a double espresso and nap 30 mins later.

CaliFlex · Post by **CaliFlex** » Tue Jan 27, 2026 5:50 am

Does the timing change for slow metabolizers?

LatinoBulk · Post by **LatinoBulk** » Tue Jan 27, 2026 6:45 am

Yes, they should dose at least 60-90 mins before. Fast metabolizers can do 30-45 mins.

MedellinMuscle · Post by **MedellinMuscle** » Tue Jan 27, 2026 7:30 am

What about the effect on calcium release in the muscle?

AndeanLifter · Post by **AndeanLifter** » Tue Jan 27, 2026 8:15 am

Caffeine increases sarcoplasmic reticulum calcium release. Direct mechanism for force production.

TropicStrength · Post by **TropicStrength** » Tue Jan 27, 2026 8:55 am

It also lowers RPE. You just feel like the weight is lighter.

LatinoBulk · Post by **LatinoBulk** » Tue Jan 27, 2026 9:40 am

Has anyone tried the 23andMe test for this?