Estrogen Rebound After Stopping AI

Recognizing issues early, managing risks, and sharing harm-reduction experiences.


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CoachIronwell
Posts: 62
Joined: Mon Dec 08, 2025 3:29 am

Estrogen Rebound After Stopping AI

Post by CoachIronwell »

Problem: I finished my AI protocol 4 days ago and now my nipples are sensitive again.

Context:
* Was using Arimidex 0.5mg EOD.
* Stopped cold turkey after cycle ended.

The Mechanics:


Is this just a standard rebound because Arimidex doesn't destroy the enzyme? Should I have tapered off?
SlavPower
Posts: 36
Joined: Mon Dec 08, 2025 3:19 am

Re: Rebound Management

Post by SlavPower »

Yes, Arimidex is notorious for this. The enzymes are just "busy" while on the drug, then they all release at once.
FrostFlex
Posts: 17
Joined: Mon Dec 08, 2025 3:16 am

Re: Rebound Management

Post by FrostFlex »

Switch to Aromasin next time. It’s a suicide inhibitor, so no rebound.
CoachIronwell
Posts: 62
Joined: Mon Dec 08, 2025 3:29 am

Re: Rebound Management

Post by CoachIronwell »

Should I start a low dose of Nolva to block the receptors for now?
manish
Posts: 0
Joined: Thu Dec 11, 2025 4:17 am

Re: Rebound Management

Post by manish »

Definitely. 20mg Nolva until the sensitivity dies down.
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